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KMID : 0828620050090020154
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Journal of Korean Arthroscopy Society
2005 Volume.9 No. 2 p.154 ~ p.161
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Histopathological Study of Cartilage in the Bone Bruise of the Lateral Femoral Condyle Associated with Anterior Cruciate Ligament Rupture
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Bae Dae-Kyung
Yoon Kyoung-Ho
Kim Hee-Sun
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Abstract
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Purpose:to describe the histologic appearance of the type III bone bruise in knees which had sustained an acute anterior cruciate ligament (ACL) rupture.
Materials and Methods:Twenty-five patients who sustained acute ACL rupture were prospectively enrolled in this study. On MRI, 14 patients demonstrated type III bone bruise on lateral femoral condyle, and 11 patients didn’t demonstrated bone bruise. Arthroscopic evaluation and biopsy of the articular cartilage and subchondral bone were performed before ACL reconstruction. Histologic and immunohistochemical evaluations were done.
Results:There was no difference between the bone bruise and control group in the hematoxylin-eosin staining for cell distribution, Masson’s trichrome staining for collagen and immunohistochemical staining for type I and type II collagen (p>0.05). But in the safranin-O staining for glycosaminoglycan distribution, the bone bruise group had an evidence of decreased staining at the superficial and middle layers, compared with the control group (p<0.05). We also found fatty change of bone marrow in calcified zone of the bone bruise group with safranin-O staining.
Conclusion:We suggest that the type III bone bruise found on MRI indicates a substantial damage to normal articular cartilage homeostasis, and may induce further damage of the articular cartilage.
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KEYWORD
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Knee, ACL rupture, Bone bruise, Histopathological study
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